It kinda comes down to how much you shoot .357 Magnum. If you want to become proficient it will take practice. Especially in proficiency firing Double-Action with full power loads above 500 Ft/lbs of muzzle energy.
It's great that Colt is bringing back the Python. I heard a few weeks back that Tom Gresham and his son were among the gun media at the Colt gathering. Tom had a Python he inherited from Grits and passed to his son, and they took it with them to the media event. Tom stated that the DA of the new Python might be better than the original, and that the new Pythons are built stronger, mentioning some incidences where full-time use of full power loads proved problematic for the original. That's been so long ago that I had nearly forgotten about it.
It will likely take some time to get past the initial surge and lack of availability for new Python sales, and the first ones will likely come at scalper's prices. Not quite in the same market as the 586/686 and the GP100 due to MSRP that's closer to the CZ owned DW 715. The Colt that was intended to compete more closely to the 586/686 and the GP100 was the King Cobra from the Mark V series that preceded it. Good revolvers, but not quite the equal of the L-Frame Smith and GP100.
For handloading with Magnum Handgun propellants like those based on W296, I long believed that 5" of barrel length was a good choice in order to get all of the powder to burn completely. The good news there is that there is a 5" GP100 readily available, albeit listed as a "Distributor Exclusive." Finding a 5" Magnum Smith won't be so easy, and prepare to pay a premium with most of them belonging to collectors.
Recently, I've been pleased with what I've seen from my full-power handloads charged with AA 11FS that is essentially a flash-suppressed version of W296. Flash is actually lower than other powders I use for .357 Mag defense type loads with True Blue for barrels shorter than 4". AA No 7 and No 9 being good choices for a broad range of loads and barrel lengths. But from the 4.2" GP100 I fire the most, 11 FS shows promise.
For those who plan to shoot at least 50% of the time with full-power loads, or plan to handload their own, the revolver needs to be up to the task. Smith L-Frames and the GP100, in particular, are very good choices.
![Wink ;-)](./images/smilies/icon_wink.gif)