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i've tried it all. both eyes open, dominant eye, focus on front site, focus on target and i get fairly mixed bag of results.
My eye's just dont do well focusing with both eyes open in the darker light of an indoor range, everything get clearer when i go to dominant eye.
Yet when I practice dry fire at home i can focus easily with both eyes open.

Focus on the target makes a lot of sense and would be most practical in a real life situation, and since you should have your arm aligned well with the barrel in an aiming position anyway it would indicate that the front site focus would be at your point of aim with your arms (or near that) anyway