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I myself have the same question as the OP. I think my biggest advantage in a hand to hand fight is to take someone to the ground as quickly as possible and use my size and weight to my advantage. Standing and trying to punch and kick or box my way out out trouble does not work to my advantage against a quicker and more physically fit opponent.

I have always leaned toward wrestling/grappling as a natural fighting style, it comes more instinctive to me. I wouldn't get caught up in which style is the best, determine which is best for you. Determine what will work to your best advantage and what you are good at.

I am thinking of taking Gracie Jiu Jitsu classes as a new program has opened up in my area. Although Karate programs are also available, having tried it before, I don't feel it's best for me as a means of self defense. If I was lighting fast and had exceptional skill I might feel different but I think Jiu Jitsu/Grappling will be much easier to learn and most effective for me. I not interested in sport,only self defense.