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I own neither of the two models you mention (we are a predominantly M&P house), but each has a stellar record for reliability. From a safety perspective, both are every bit as safe as the user. From a usability standpoint there are really two big differences between the platforms -- different trigger actions and different grip angles. Some folks prefer a single action trigger like the Glock to a double action/single action trigger. Likewise, some folks are strongly aligned on the "traditional" grip angle of the SIG/1911/M&P and numerous others whereas the Glock is a bit different. It may be a natural pointer for you, though.