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This has been discussed by newbies in every gun forum in the country, and I don't know how many times in this forum. You don't have to search very far or very hard to find real-life cases where a handgun was used for self defense under circumstances where the person would have been unable to cock a hammer or rack a slide. There was one recent case where a woman was attacked and pushed into the car with a 200 lb man on top of her. If she needed two hands, she would not have been able to shoot him.

Most self defense situations are at contact distance. You may very well be fending off an attacker with one hand while drawing and shooting with the other.

If you are uncomfortable with the idea, work on your gun handling skills. Try IDPA.