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I've been slowly consolidating both calibers (and guns) over the last 10 years (partly because back when I started I was doing a lot of reloading, so that adds another layer of incentive; had three Dillons up and running for 38, 45 and 40.) No surprises as to my choices: .22/.38-357/.40/.45, 5.56 and 7.62 for rifles, and 12 GA.

Stash a few thousand rounds of preferred calibers in ammo cans and you can weather any temporary shortage. NATO standard played heavily into rifle decisions - I figure when we are up against the UN we can take their supplies :)
Although I also still have a 380 and a 9, I treat those as 'buy as you go.' Thinking hard about unloading the 9 since it seems a bit redundant with the 40 and less effective, but then there's that NATO thing again...