1) A safe should sufficiently deter "smash and grab" criminals. That means it's out of casual visibility, bolted to the floor or wall, and has the door side (perhaps) along a wall or in some other position to prevent pry attempts.
2) Unless your items are incredibly valuable, you probably don't need a vault room or similar Charlton Heston-like fortress :)
3) A professional thief that wants your gun collection is likely to go through the extra effort to get your valuables in your safe because that's their high value target. If this happens, you're hopefully already smart enough to have those things insured, because he's going to rent a plasma cutter for $100, smash your door down, and be in and out of your house before the cops arrive. Yeah, he already knows how long the police response time is, how much work it will take to ingress, and where your safe is. The good news is, this really only happens in the movies
Seriously though, get your safe out of sight and bolt it down, or have somebody do it. Otherwise your safe can just be construed as a heavy shopping cart for the bad guys.