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I carry anything from a LCP 380 to 9mm in different sizes to a full size M&P or 1911 in 45 ACP depending on the situation. I will say that I prefer a full size 45 ACP. I have no personal experience in this but have talked with several big city SWAT team members that have had to shoot more than a few people in the line of duty. They all say the same thing, the bad guys just seem to go down faster when hit with a 45. I tend to listen to those with real world experience.