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I carry with one in the pipe and the safety(wish I could just remove it from my taurus 709) in the off position. Of course, with my Glock and my J-frame, the only safety is between my ears. My father-in-law always says, "don't put your booger hook on the trigger until you're ready to shoot something." I think that is the best advice I can give, as there have been may times when I am hunting in low stress situations and gotten nothing off but a dead stop in the trigger and a shoulder flinch, rather than firing a shot, only to have my target walk, run or fly away....but I do still always use my safety when I'm hunting. Good luck, and may you find a method which suits you best.