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Lots of good responses. Bottom line is you are not obligated to get into a physical confrontation with someone regardless of size difference. If you are confronted and do everything you can to be calm, get away from the person, and leave the area, but the aggressor persists and physically attacks you, you are in the right to defend yourself with a weapon, regardless of your size. If I were on a jury, I would be looking to see if both parties were mutual combatants prior to the violence.
Where you have to be careful is in the pre-fight exchange. If a guy is trash talking, and you are trash talking back, you both are throwing the bird and being nasty, he walks over and pops you in the jaw and you shoot him, you may have a problem. My uneducated opinion is that everyone, particularly bigger guys, need to make a clear effort to avoid the confrontation before shooting. A smaller person, I would believe, probably has more leeway. If you are trying to get away and a little guy attempts to attack you physically, I believe you are justified to stop him. Just my two cents, others may disagree.