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My suggestion if you want a dedicated .22 handgun is the S&W M&P Compact. Good ergonomics, good trigger, good accuracy with correct ammo, reasonably priced and my has eaten everything I have fed it. IMHO, the only thing they could have done to improve it would have been to use double stack magazines which would have given you about a 17-18 round capacity instead of ten. The R&D would have been more, but the increased manufacturing cost would probably have been less than $3.

Your other option is to use a .22. conversion kit which are available for many Sigs (from Sig), Glocks, and 1911s. I think there are even some for CZs (from CZ).