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If you skip down 54 to 82 you'll go through Cloudcroft, NM. A nice little mountain town. Once out of the mountains of NM you'll be in dry, flat open land. There is a certain beauty to it, but it wears off pretty quickly. You'll probably skip down to 62 at Lovington, NM unless you go south at Artesia on 285 to Carlsbad. You could pick up the caverns if you've never been there before. You'll be on flat dry roads until you drop off the caprock either at Post (380) or Gail (180) then the scenery gets a little more interesting as you head home.

As GAH stated, 380 keeps you closer to Lubbock and avoids more of the oil field traffic, especially once you're east of Post but then you're pretty much on your own until your almost home. 180 will keep you closer to I-20 if you need a place to bail.

Other than these few details there is not much difference in the scenery.