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I carry the same type of guns but not the same caliber. I don't carry anything with a manual safety that has to be removed or don't mix revolvers with pistols. I usually carry .45 in the colder months and 9mm or .380 in the warm months.

I try to shoot more when going from 9mm to .45 than the other way around simply because I have found my accuracy decreases. I guess it has to do with grip size and maybe recoil. I try not to switch once I start carrying one or the other because I find I don't grip the gun correctly if I switch back and forth. I use the same holster most of the time so the gun rides in the same place on both calibers. I plan to get a XD45 Compact and carry it for the cold and XD9 SC in the summer. I like the XD45 Compact and while the grip is larger it is closer than going from the XD9 to a Glock 21 or 30 and back.

Short answer is I try to standardize platform and caliber, and may someday, but I don't obsess about it. I just work with what I have and try to be aware of any transitions and do what is necessary to adjust.