I carry and handle every gun as if it was going to fire if I touch the trigger. I mainly carry Springfield XDs now because I like them overall and I like that I can handle it without touching the grip safety. I am much more confident with an XD than with my Glocks because of that. I also intentionally bought a IWB that I cannot reholster while on my body so I would have to remove it, place it on the weapon, and return the gun and holster to my belt. I think once my gun is drawn I will chance any situation where reholstering is a must. Depending on the holster you use, this may be an option to get around any concern of ND while reholstering. Again, I would not carry a gun that was not ready to fire when I needed it. The noise of chambering a round is enough to get a CHL holder shot and destroying any advantage of surprise. It also takes away the opportunity to pull and fire in a moment the BG gets distracted.
Main thing is, pay attention when handling the firearm. If it cannot be done with all your attention then don't do it.
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