What I'm wearing any particular day dictates what gun I'll be carrying. Shorts and t-shirt; .380 or .38 snubby. Jeans and polo's or hawaiian's; 9mm (either Taurus or Ruger). Dressed up (sunday-go-to-meeting clothes); Taurus 24/7 in .40 (and soon to be in my holster... a Taurus PT1911
)
I go to the range and practice enough that I have good muscle memory on all of them (especially since if it's not in my pocket, it's always in an IWB at 2:30/3:00 on my strong side.)
In the house we have strategically located weapons, but rely mainly on the shotguns for PD.
