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I have shot 4 .22lr semi autos and like you I know I need to buy one.

1. Browing Buckmark Camper
2. Ruger MK III
3. Walther 22
4. Beretta Neos

Browning- Feels nice in the hand. Was pretty accurate and from what the owner told me not to bad to strip down.
Ruger MK- When you think of .22lr semi auto handgun this is it. Very accurate for the one I shot. I think it is about a 5in barrel and ran reliable just like the browning. My dad hates stripping it down though. He says it is hell!
Walther p22- My brother had it for years and then sold it. Grip was nice for a concealed .22 but it was not that accurate and it would jam every couple of mags.
Beretta- The ugliest thing I have ever seen and this is what I plan on buying. Why? It is very affordable! Easy to breakdown and in the 6in barrel I shot it was more accurate then the Buckmark. Feels ok in the hand and never jammed with over a 100 rounds down range. Heavier then it looks. Easy to break down.

If your on a budget like me and want the best bang for your buck get the neos. Other then that I don't think you could go wrong with the Browning, Ruger or the other that I have heard is nice is the CZ Kadet.