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I try to use a powder that will fill the case as much as possible for the round that I'm shooting. So this generally means that the shorter the cartridge, the faster the powder.

I also like to compress the powder a little.

I found that by filling the case as much as possible and compressing it a little, I got greater consistency in the velocities, accuracy, and pressures. (I'm one of those geeks that has actually used a pressure barrel hooked up to a laptop.)