I think you have it backwards.Just sayin... but if I got stabbed with that blade, I wouldn't be worried about the .22 round getting shot in as well. The Blade's more than enough.
I would use the 22 first (Longer range) and if the person were dumb enough to keep coming I could use the knife as backup.
Come to think of it, weren't the early firearms this way?
One shot then you use your weapon as a stabbing tool?