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From an engineering standpoint it won't hurt a thing to keep it cocked and ready to fire at all times. The mechanism of modern handguns is designed for that environment from the get go.

Where this idea that keeping a spring compressed for a long time was bad for reliability is from long ago when we didn't have the modern steels that are more rust resistant than they were back then. It is easy to understand how a spot of untreated rust on a spring creates what in engineering jargon is called a "stress riser" that will eventually fail. It's simply a case of the steel wire of the spring being thinned by the rust until finally it is too small to hold the load and it breaks. If you keep your springs well cleaned with a bit of rust proofing oil on them you'll never have that problem. They will last for as long as they are taken care of.