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Lock the guns up. How to approach that with your friend all depends on the stage of this horrible disease that he is in. From personal experience, I can say that it will only get worse. Having access to a firearm of any kind is a terrible danger to all the people he is around while going through this. If he still knows you, there will come a day when he doesn't. IMHO you will be helping him best by acting now why you still can.