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Medical anomalies and disorders aside, weight loss is simply consuming less calories than you burn. There is no magic number of calories to burn or miles to walk, every person is different. I would suggest having a body analysis done to determine approximately how many calories you burn per day, then subtract a healthy amount (once again everyone is different) to put yourself into caloric deficit. Then you can focus on doing the activities you enjoy. Weight loss is 80% in the kitchen.