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I do not carry a knife for fighting, just a subcompact to full size gun, depending on clothing.
What I found out over the years is that a kick with your boots on the chin or a bit lower in the groin of an opponent is the best choice. A good hit with the fist on the nose is practical as well. Once it comes to close contact it gets dirty and you have to be dirty, as dirty as possible if you want to win. Most important, stay fit! Couch potatoes are typically not in this category and therefore a bit more at risk in case. And BTW, no matter, gun, knife, golf club, if one is not fit he/ she is most likely over challenged in a bad situation.