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May I suggest that the best way to carry is for you to decide which way works best for you? Personally, I carry with a round in the chamber and the hammer cocked with the thumb safety on (a 1911, if you could not tell). I have carried that way since the Army stopped making me carry with an empty chamber 35 years ago. Since then, I have also carried striker fired pistols with a round in the chamber and a revolver with with a full cylinder load.

If you are uncomfortable carrying that way, find the way that makes you feel better, even if that is with no round chambered.Your personal attitude will be the determining factor in how you carry, as it should be. But, to help you decide, look at how your local police carry their weapons. Then look at how many unintended shots they have fired. Check which weapons they carry and how the rounds were fired, also.

I have a personal bias towards 1911s though I do think Glocks are good guns. I would be almost willing to bet that if you check what weapons have the most unintended discharges, it would be Glocks. That could be because they are so common in police work, but it could also be because they do not have the external safety that 1911s and other pistols do. I have not done a proper study on this, so it is just a seat of the pants estimate, fueled by bias, so I could be wrong. It is just something to consider, IMO.