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LikesShinyThings wrote:[snip] Glocks are considered fine firearms by many. I won't praise or condemn them. I will say I can't shoot them. If you don't have a rock solid grip on them, they WILL misfeed - my experience being FTE. I have had more stovepipes than I care to count.[/snip]
Welcome..texanron wrote:Snip\ In your OP you stated that you're from Connecticut and that you're a Mechanical Engineer. Given those two facts and that you said in your second post that shooting a .40 S&W hurt your wrist, I would recommend that you go with 9mm.
..and don't feel bad, I'm working on a Biomedical Engineering masters so I'll have to go with the 380. J/k 
I shoot both the 45 and the 40, from Glocks primarily, but I have no wrist issues. You get 13+1 in the G21 45 and 15+1 in the G22 40s&w. The 45 in these guns produces significantly less muzzle rise with the recoil headed straight back into your palm. The 40 recoil goes straight up, jerking the wrist, even in the fullsize model (G rated forum). If the mag cap is an issue, it's a no brainer, go with the 45. I do not own a 9mm. For what it's worth, I don't carry a 1911 because IMO (15x3)+1=46 is better than (8x3)+1= 
. Sorry to all the 1911 guys, I couldn't resist. 
Disclaimer: 1911's are perfectly suitable defense weapons to consider. Whatever you decide on though, pick up the .22 conversion kit for it if it is available and financially feasible. That way any practice time you get will be cheaper and on the same trigger, unless you just WANT to buy another gun. BTW they are about the same price, .22 conversion or .22 pistol.