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I currently alternate between a Colt Defender and a Kimber Ultra Eclipse II. The Kimber's the more accurate/controllable of the two for me, but its empty weight is comparable to the loaded weight of the Colt. I'm currently debating selling/trading the Colt, but am not yet sure about it; despite the fact that it routinely -THWACKS- me in the forehead with brass, I'm kinda fond of it. (BTW, that problem disappears with quality, "hot" defensive ammo. It seems the pistol prefers the hotter ammo).
The Kimber's more finicky about cleanliness, though, while the Colt's never jammed, not once (not even when I had to scrape the powder crud off the rails with a brass brush and lots of solvent).

I'll probably keep and carry both for a good long while. The Kimber's my classy gun, the Colt's my knockabout pistol. And both, when clean and maintained, are highly reliable, extremely potent, and very concealable; I feel undergunned with neither.