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TAM is spot-on about being able to switch between different but familiar shapes. I think it's a good idea to break training on your primary now and then with something different, especially if it's something you might have to use in a bad situation. Wife's pistol, service pistols common to your area, what your buddy carries ... I wouldn't like to think that I just couldn't shoot a particular pistol because of its grip configuration, especially one so common as a Glock.

I shot a Glock19 when they first came out. It felt a little odd, but nothing truly weird. The next time was for CHL qualification, where the Glock 19 just shot pretty much where I aimed it. The rental and ammo were included in the course price, so I left my Colt in the case. I just watched that front sight a little harder.

Lugers are a little odd, but the one I've shot made me worry more about the trigger and sights than the grip configuration. It had a truly bad trigger.