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With the exception of my two .380s, I would be comfortable in a fracas with any of the handguns in my safe.

I have 4 guns in my carry rotation (more than that in the safe, but I use only 4 for carry purposes). Three are .45 semi-autos, the other a .357 revolver. Of the .45s, two are 1911s, and one is an M&P. I wouldn't carry any of them if I wasn't confident in my ability to shoot them. That said, even though my 1911s own my heart, I would probably choose the M&P 45 as a last ditch gun. I shoot it nearly as well as I shoot either 1911, and it carries a couple more rounds (10+1) than my Springfield (8+1) or my Kimber Ultra (7+1). I have 4 magazines for it, so a 40+1 round loadout only requires 3 reloads instead of 4 if I wanted to carry 40+1 rounds for my 5" 1911, and 6 reloads for my 3" 1911.

But all of that is purely hypothetical. I don't ever plan on having to maybe do one reload (while I'm running away), and I don't bother carrying 41 rounds of .45, else my pants would always be falling down.