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I carried my Glock with an empty chamber for a long time.

With plastic practice rounds, I rehearsed sling-shotting the slide. Eventually, I was very efficient at doing this.

As time passed, I noticed that I'd never unexpectedly stroked the trigger, practicing or carrying.

Now, I carry with a round in the chamber with a 3.5lb trigger.

If prompt presentation is necessary, having to deactivate a safety may take your focus from where it need be or chambering a round while under great stress (also a focus distraction) is for me far more dangerous...

Of course, as mentioned, I had to go through the initial "getting comfortable" phase first with the current carry status.