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I think every one who reloads should take stock of this current shortage. Develop a plan on what type of powders to keep well supplied with.

With Handguns my 3 powders would be:
1- Bullseye (or WW 231) Works in almost all handguns.
2- Unique (or Herco) these are good for shotguns and cast bullet loads in rifles.
3- 2400 (I choose 2400 over H-110 because you can load magnums down with it to Unique velocity levels and works in rifle cast bullet loads)

Rifles
1- IMR-4064 ( Will work in rifles from 223 / 30-30 / 243 / 30-06 / 300 Win Mag and too many others to list) Of course other medium burners will do just as well but this one works for me.

2- IMR 4350 or 4831 Which ever you find cheapest go with it.

These 5 powders will allow you maximum flexibility in keeping you guns running.

The following figures help with primer and bullet balancing with powder

8LB powder = 56000 grains

8 LB Bullseye / 3grs = 18,666 38 special loads. Keep 20,000 pistol primers for every 8LB jug
8LB Unique / 6grs = 9, 333 .45ACP loads. Keep 10,000 LP Primers per 8LB Jug.
8LB 2400 / 15grs = 3,733 .357 mag loads Keep 5,000 Pistol Primers per jug.

As you can see pistol powder goes a long ways compared to the number of primers required to load an 8 LB jug.

Rifle powders are different you will only get around a 1,000 loads per 8 LB jug, so 5,000 rifle primers requires 5 jugs of powder. Much more difficult to stock up powder for extended shortages.

Take care

Hank