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Are you trained in applying handcuffs, plastic or otherwise? Do you know body pressure points to get a person to follow your commands?

Even if the answer is yes to both above,.......are you sure the perp is the only one there that is a threat to you? Even if he/she is, do you think it is wise to get close enough and use your guard hand to try and apply handcuffs to them?

How about just handing the handcuffs to them and ordering them to put them on? What are you going to do when they tell you where to go and start running?

See my point?

Stop the threat, call the Police & report. Forget about any handcuffs and leave that to the Police.

NOTICE: And this comes from someone who is in fact trained in the use of handcuffs!