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My normal primary carry is a Kimber Pro Covert II. If I'm not carrying it then its either a Rock Island Armory compact Tactical or a Kimber Custom TLE II. If for some reason I'm not carrying one of those three I will most likely be carrying an XDm in either .40 or .45. So in essence four out of five of the guns I'm likely to carry as my primary are chambered in .45 ACP.

My suggestion is simply find a reliable gun you like and can shoot well then buy it, break it in, and carry it in a good high quality holster. Caliber is secondary to shot placement. As far as guns I have no problem recommending goes I feel comfortable recommending people consider products from Sig, Kimber, Rock Island Armory, Springfield Armory, STI, Glock, Smith & Wesson, Ruger, H&K, ect. If you will notice there is a pattern to those, they are all companies that have reputations for building quality products. Now I will admit some are a bit more costly than others, but after they are broken in and are properly maintained they will work.